Kreyòl

DNA Glycosylase

• Explore the relationship between a protein’s structure and its function in a human DNA glycosylase called human 8-oxoguanine glycosylase (hOGG1). Part 1 is appropiate for advanced high school biology courses and introductory undergraduate biology courses. Part 2 is suitable for advance undergraduate biology courses.

Hemoglobin & Sickle Cell Anemia

• Explore how a single alteration in the amino acid sequence of the hemoglobin protein results in sickle cell anemia, a genetically-inherited blood disorder. Appropriate for high school biology courses and introductory undergraduate biology courses.

Macromolecules

• This exercise explores the four classes of biological macromolecules. Appropriate for high school biology courses.

Phenylalanine Hydroxylase & PKU Disorder

• Explore the relationship between the structure of a mutated form of PAH and the function of this mutated protein in patients with phenylketonuria (PKU), a genetically inherited disorder that is characterized by the inability to utilize the essential amino acid, phenylalanine.ppropriate for introductory undergraduate biology courses.

Phosphofructokinase (PFK)

• Explore the structure and function of the enzyme phosphofructokinase (PFK), the most important regularoty enzyme of glycolysis. Appropriate for introductory undergraduate biology courses.

Ras and Cell Signaling

• Ras proteins are essential components of various signal transduction pathways that regulate growth, proliferation, differentiation, and apoptosis. In this exercise you will explore the structure of the Ras protein in its active and inactive states and the amino acids that contribute to these two states. Appropriate for introductory undergraduate biology courses.